In the one webcomic I'm actually publishing, the protag is female. I really wanted to write a sci-fi adventure story with a young girl protagonist who was good with tinkering with stuff but was also really girly (her hobby is dressing up really fancy, which will make an appearance in the comic soon). The supporting character chooses a male pronoun, which I wanted to do because AI in sci-fi tend to have female voices and I wanted an AI that intentionally chose a male voice and pronoun. He's got a bit of a Pinocchio complex goin' on.
In my other story that I'm working on, (paranormal/action/sci-fi) the protag is male, with a 50/50 split between the other characters (er... make that like 40/40/20 split because there's a bunch of supernatural creatures whose sense of gender is... fluid, to say the least). And in my other (political sci-fi) story, I have a pair of protagonists - a female character (4th princess, with ambitions to take over the Empire) and a male character (common-birth young man who joins up with the brewing socialist revolution). It's not a love story and they don't end up together. In general I have a fairly even split of genders, though I do notice a tendency to a) skew the female characters older relative to the male and b) place all the female characters in positions of power just because I find it more interesting to write about ruthless women than ruthless dudes (what haven't we seen at this point, lol?). I did actually have to re-allocate power once because I was just like hold up, the Emperor, the Admiral, the Chancellor and these five important scientists and rebel leaders are ALL women, except for this one guy? I mean, I'm all for it, but it didn't ring true to the world-building.