For me it's mostly art style that gets me interested. I like art styles that are pretty unique, stylish, and out there and won't always keep reading if the style doesn't grab my interest. It's EXTREMELY rare for me to get interested in a story if I'm not into the style. (not saying I won't read anyway, especially right now when I'm trying to focus on making connections with folks regardless of their style, but once I'm more settled it'll probably be more rare since I just don't have that kind of time to keep up with stuff I'm not feeling)
Subject matter also matters a lot to me. There are a lot of genres I just straight up don't care about. They could be the most well written thing in the universe, but it'll be very hard for me to care about it simply because of the genre. Give me something from a genre I love and it won't matter how stupid the story is.
I've just seen so many films and ready so many books and played so many games that I kinda hit a point where I'd just rather see things I don't feel like I've already seen a thousand times over.
Also the weirder it is, the better. So basically, if it's weird, has a unique style, and isn't a genre I dislike, you'll have my attention. If you don't, though, it DEFINITELY does not mean it's a bad comic or anything, nor would I call all the ones that do, good. I just have very specific preferences that a lot of comics just don't hit the mark on.